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Molecular difference may explain IBS symptoms

Patients with irritable bowel syndrome (IBS) have molecular alterations in their gut, a new study finds.

In the study, University of Vermont researchers compared tissue biopsies of IBS patients with those of healthy volunteers. They found changes in the serotonin signaling of IBS patients, which may explain their symptoms of abdominal discomfort, pain, bloating, constipation or diarrhea.

Serotonin is a naturally occurring molecule largely found in the gut. It plays a role in gut motility and secretion, and signalling to the brain and spinal cord.

Lead investigator Associate Professor Peter Moses said that the finding supported the notion that IBS was not simply a psychological or social disorder as was once thought, but was instead due to altered gut biochemistry and interactions between the gut and brain.


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